arm64
Apple Silicon
M1, M2, M3, M4, M5 and later M-series chips
macOS 14 Sonoma or newer
Test on Apple SiliconVerify download (SHA-256)
128c80508e23b452ac67e8857217778c345ece7584b8a58edfb83b06599dfa18SIMLAB DESKTOP
Your molecular workspace.
On your computer.
Visualize structures, dock molecules and prepare simulations in one desktop app. Your local scientific tools are bundled and ready to use.
GET THE APP
Choose your operating system
Separate builds for the right architecture.
macOS
Choose the chip inside your Mac.
x64
Intel
Intel-powered Macs
macOS 14 Sonoma or newer
Test on IntelVerify download (SHA-256)
d600799fd688e79faf3fa8faa979b18c86293e3fc6e30aa80763dca4275978b7Windows
For 64-bit Intel and AMD computers.
x64
Windows 64-bit
Intel or AMD PCs running 64-bit Windows
Windows 10 (1809+) or Windows 11
Download for Windows 64-bitVerify download (SHA-256)
7d2b03ca8a336f92649747cce021b95c70db14baab8f81de7d2bc9cc82bb95daInstallers include the scientific engines. Allow additional space for installation, projects and simulation results. Keep your existing projects backed up when updating.
Not sure which download to choose?
On a Mac
Open Apple menu → About This Mac. If it lists a Chip such as Apple M1 or M4, choose Apple Silicon. If it lists an Intel processor, choose Intel.
Both editions require macOS 14 or newer.
On Windows
Open Settings → System → About → System type. Choose this installer for a 64-bit operating system, x64-based processor.
A 32-bit Windows edition and a native Windows ARM edition are not currently available.
ACTIVATE YOUR WORKSPACE
Your desktop license, right here.
Copy the shared license below and paste it into SimLab Desktop when it first opens. No separate license account is needed.
Connect to the internet for activation.
Desktop activation is separate from GPU Compute. Compute requires your own SimLab account, access and credits.
FROM DOWNLOAD TO FIRST PROJECT
Installation, step by step
Install on macOS
The current Mac downloads are installation-test builds. Read the Mac test status before installing.
- Download the matching Mac edition.Check your chip and macOS version using About This Mac.
- Open the .dmg file.Drag SimLab Desktop into your Applications folder. If updating, quit the running app first.
- Open SimLab Desktop.Launch it from Applications, then paste the shared license while online.
- Start exploring.Open the Viewer directly, or create a project and import your structures.
If macOS blocks the first launch
After attempting to open the app, go to System Settings → Privacy & Security. If you trust this download from simlabscience.com, use Open Anyway when offered and confirm. Keep your system’s security settings enabled.
Apple’s instructions for opening an app ↗Install on Windows
- Download the 64-bit installer.Save the .exe file to your computer and wait for the download to finish.
- Run the installer.Choose your installation location and follow the setup steps.
- Launch SimLab Desktop.Open it from the Start menu or desktop shortcut, then paste the shared license while online.
- Open a structure or project.The scientific tools are included; no separate GROMACS or Python installation is needed.
If Windows shows a protection prompt
Check that the file came from simlabscience.com and compare its SHA-256 checksum above. If you trust the file and Windows offers the option, select More info → Run anyway. If your organization blocks installation, contact its IT team.
RELEASE NOTES
A connected scientific workflow
Version 0.1.8 · Early access
- Monitor production in the app. See job status, step progress and recent logs, and download available result files directly.
- Process and analyze results. Remove PBC from completed protein trajectories, then send the corrected trajectory to the in-app Analyze window.
- Customize your plots. Time-based plots use nanoseconds. Edit chart titles and axis labels; residue-based plots retain the appropriate axes.
- Inspect and visualize. Explore structures, representations, residues, trajectories and molecular interactions. Export images and molecular files.
- Prepare, dock and build. Repair receptors, select curated or imported ligands, dock and prepare systems for simulation.
- Work locally. Connect when needed. Local calculations run on your computer. GPU Compute, PubChem and structure fetching require internet access.
- Bring your own prepared system. Connect to Compute and upload systems built elsewhere, with multiple minimization and equilibration stages.
A few useful answers
Do I need to install GROMACS, Python or RDKit?
No. The desktop installers include the tools needed by the supported local workflows.
Can I work offline?
Activate while connected to the internet, then use the local tools offline. Online services—including GPU Compute, remote DFT and fetching structures or compounds—need an internet connection. License validation may also require reconnecting.
How will app updates work?
Version 0.1.8 is available here as a manual early-access download. Automatic update feeds remain on the previous release while installation acceptance is pending. The app can check for a newer release while online and offer Update now or Remind later. Finish local jobs and quit SimLab before installing an update. Updates use the download channel for your operating system and architecture.
Why is the download large?
The installer includes scientific engines, a Python environment and ADMET model files so local work does not depend on installing those tools separately.